云南省疟疾防治研究所  李华宪  黄国珍

全文发表于《中国寄生虫防治杂志》1990年第3卷第2期115-117页

 

提要：本文观察了3例思茅的间日疟病人顿服氯喹（基质）600mg＋伯喹（基质）22.5mg、2例勐腊的恶性疟病人顿服乙胺嘧啶70mg＋周效磺胺100mg＋伯喹（基质）22.5mg后，药物在蚊体内抑制疟原虫孢子增殖的效果。结果显示：服药后8h内两种疟原虫在吸血蚊体内仍能进行孢子增殖；间日疟原虫配子体在24～96h内转阴，服药后12h～10d内中华按蚊未受感染；恶性疟原虫配子体在10d内未转阴，服药后12h～9d内大劣按蚊未受感染，其中1例于d10复燃并使大劣按蚊重获感染。结果提示上述服药方法用于防止传染源境外输入时，对入境留宿的边民最好在蚊媒活动8h以前给药。

关键词：疟原虫，配子体，孢子增殖

 

EFFECT OF COMBINED USE OF CHLOROQUINE/PRIMAQUINE AND PYRIMETHAMINE/SULFAMETHOXINUM/PRIMAQUINE ON THE SPOROGONY OF PLASMODIUM VIVAX AND FALCIPARUM IN ANOPHELES VECTORS

Li Hua-Xian, Huang Guo-Zhen

Yunnan Provincial Antimalaria Institute

 

ABSTRACT.  th vivax malaria was more than 100／u1 and with falciparum malaria，70／ul.

The results showed that the administration of these drugs did noThree patients with vivax malaria from Simao and two patients with falciparum malaria from Mengla were treated orally with acombined dose of chloroquine 600mg／primaquine 22.5mg and pyrimethamine 70mg／sulfamethoxinum 1000mg／primaquine 22.5mg respectively，for observing the effects of the drugs in restraining sporogongy of the parasites in Anopheles veotors. The number of gametocytes in blood from the patients wit restrain the sporogony of P. vivax in An. sinensis and P. falciparum in An. Dirus within 8 hours after treatment. The gametocyte clearance time of P. vivax was 24 or 96 hour，but An. sinensis could not infected 12 hours later or in 10days. The gametocyte of P. falciparum was not cleared as observed for 10days, while it also could cause the An. dirus to be infected.

These results suggest that the time of medication should be 8 hours before contacting with Anopheles vectors when the method is used for preventing the import of the sources of infection.

 

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