杨恒林  杨品芳  董莹  车立刚  何慧     云南省疟疾防治研究所  思茅  665000

刘德全 刘瑞君 詹斌 张春勇  高大庆   中国预防医学科学院寄生虫病研究所 上海 200025

全文发表于《中国寄生虫学与寄生虫病杂志》1994年12卷1期31-33页

 

提要：应用WHO推荐的体外微量测定法于停用氯喹前的1981年及停药后的1984、1988－1990和1992年在云南省南部的勐腊县测得恶性疟原虫对氯喹的抗性率分别为97.4％、100％、96.1％及93.7％；ID₅₀依次为170、132、125及110 nmol/L，ID₉₅灰1000、740、707及576nmol／L；平均抑制量分别为55.4、46.7、45.8及35.4pmol／井。与1981年测得结果相比，抗性率无明显变化；ID₅₀分别下降22.3％（P＜0.05）、26.4％（P＜0.05）及35.3％（P＜0.01），ID₉₅依次下降26.0％（P＜0.05）、29.3％（P＜0.05）及42.4％（P＜0.01）。平均抑制量分别下降15.7％（P＜0.05）、17.3％（P＜0.05）及36.1％（P＜0.01）。提示云南南部恶性疟原虫对氯喹的抗生并不稳定，而是随药物压力的下降而降低。

关键词：恶性疟原虫，抗性，氯喹，体外微量法，纵向监测

 

LONGITUDINAL SURVEILLANCE OF CHLOROQUINE RESISTANCE OF PLASMODIUM FALCIPARUM AFTER CESSATION OF MEDICATION IN SOUTH YUNNAN

Yang Heng-lin, Yang Pin-Fang, Dong Ying, Che Li-Gang, Chen Wen-Cai, He Hui

Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

Liu De-Quan, Liu Rui-Jun, Zhan Bin, Zhang Chun-Yong, Gao Da-Qing

Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, Shanghai  200025

 

ABSTRACT. The resistance of P. falciparum to chloropuine was assayed by in Vitro microtest in 1981 and after cessation of medication in 1984,1988－1990 and 1992 in south Yunnan Province of China. The resistance rates were 97.4％（38／39），100％（25／25），96.1％（73／76）and 93.7％（59/63）, respectively；ID₅₀were 170，132，125 and 110nmol／L；ID₉₅ were1000,740,707 and 576nmol/L；mean dosages for complete inhibition of schizont formation were 55.4，46.7，45.8 and 35.4 (pmol／well). A comparison of the results in 1981,1984,1998－1990 and 1992,the resistance rate showed on marked change,ID₅₀ dropped 22.3％(P<0.05)，264.％（P<0.05）and 35.3% (P<0.01)；ID₉₅declined 26.0%(P<0.05), 29.3%(P<0.05) and 42.2% (P<0.01); mean dosage of inhibition dropped 15.7% (P>0.05), 17.3%(P<0.05) and 36.1% (P<0.01). The results show that the extent of resistance in chloropuine-resistant P falciparum to chloropuine in south Yunnan has been declined markedly, indicating that coresistance was variable and dropped along with the declining of drug pressure.

Key words：Malaria, Plusmodium falciparum, resistance, in Vitro test, chloroquine, longitudinal surveillance

 

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