杨恒林  杨品芳  杨亚明     云南省疟疾防治研究所  思茅  665000

全文发表于《中国寄生虫学与寄生虫病杂志》1994年12卷2期140-142页

 

提要：1992年10－12月在云南南部应用体外微量法测得甲氟喹、奎宁、氨酚喹、氯喹、磺胺多辛／乙胺嘧啶（磺／乙）及咯萘啶对恶性疟原虫的ID₅₀依次为46、480、52、150、2x 10⁴／25×10²及15nmol／L；ID₉₅分别为160、1536、292、680、24×10⁵/3×10⁵及60nmol／L。恶性疟原虫对甲氟喹、奎宁均敏感；对氨酚喹及氯喹的抗生率分别为100％（30／30）及96.7％（29／30）；咯萘啶测定5例，其中1例显示有抗生。20例中有的13例的恶性疟原虫可在最高药量磺／乙井中发育至裂殖体，提示当地恶性疟原虫对氯喹与氨酚有明显交叉抗性，对奎宁与甲氟喹可能有交叉抗性。

关键词：恶性疟原虫，体外微量法,甲氟喹,奎宁氨酚喹,氯喹，磺胺金辛，乙胺嘧啶，咯萘啶

 

IN VITRO SENSITIVITY OF PLASM ODIUM FALCIPARUM TO MEFLOQUINE, QUININE, AMODIAQUINE, CHLOROQUINE, PYRONARIDINE AND SULFADOXINE / PYRIMETIAMINE IN SOUTH YUNNAN

Yang Henglin, Yang Pinfang, Yang Yaming

Institute of Malaria prevention and Treatment of Yunnan Province, Simao  665000

 

ABSTRACT. The sensitivity of P. falciparum to mifloquine, quinine am odiaquine, chloroquine pyronaridine, and sulfadoxine / pyrimethamine (MEF, QNN, AMO, CHL ,PYR,S/P)was tested using in vitro microtest in south Yunnan Province in 1992. The ID₅₀ were 46, 480, 52, 150, 2x 10⁴／25×10²nmol/L, and 15nmol/L; respectively;ID₉₅ were 160, 1 536, 292, 680, 24×10⁵/3×10⁵nmol/L 60nmol/L, respectively, All the isolates(30) were sensitive to MEF and QMN;100%(30/30) and 96.7%(29/30) isolates were found to be resistant to AMO and CHL, the cross-resis-tance rate was100% to the two drugs. One of 5 isolates exhibited resistance to PYR.The results suggest that the P. falciparum was susceptible to MEF and QNN,but was resistant to AMO,CHLand S/P.CHL-resistant P. faleiparum showed a marked cross-resistance to AMO, but not to MEF,QNN,and S/P; AMO-resistant P. falciparum exhibited cross-res is-tance to CHL, but not to MEF, QNN,and S/P.

Key words: Plasmodium falciparum, in vitro seisitivit, mefloquine, quinine, amodiaquine, chloroquine, sulfadoxine / pyrimethamine

 

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